What is CBDa?

CBDa (Cannabidiolic Acid) is the acidic precursor to CBD (Cannabidiol), found in raw cannabis plants. CBD is obtained through decarboxylation (heating) of CBDa, altering its chemical structure and effects (Takeda et al., 2012). CBDa is known for its various therapeutic effects.

Here's a summary of the latest research findings on CBDA:

Anxiety and Fear Reduction: CBDA shows promise in reducing anxiety and trauma-induced fear. A study found that while CBD disrupted cued fear memory expression, CBDA normalized trauma-induced generalized anxiety-related behavior in mice, without affecting contextual fear expression (Assareh et al., 2020).

Neuromotor Tolerability: In terms of neuromotor effects and feeding behaviors, CBDA is well-tolerated and does not exhibit the sedative side effects typical of benzodiazepines. It also shows anxiolytic-like behavior in certain test conditions (Brierley et al., 2015).

Influence on the Sleep-Wake Cycle: CBDA and its stable analogue, CBDA methyl ester, affect the sleep-wake cycle, suggesting potential modulatory effects on sleep and associated neurochemicals (Murillo-Rodríguez et al., 2021).

Antioxidant and Anticancer Effects: Studies on hemp oil enriched in cannabidiol (CBD) by decarboxylation of CBDA have demonstrated antioxidant properties, as well as selective apoptosis induction and ROS production in cancer cells (Petrovici et al., 2021).

Potential in Treating Obesity: A CBDA derivative showed efficacy in reducing body weight, hyperphagia, and improving metabolic profiles in models of diet- and genetic-induced obesity (Ben-Cnaan et al., 2022).

Anti-Inflammatory and Antihyperalgesic Effects: CBDA has demonstrated anti-inflammatory and anti-hyperalgesia effects in animal models of acute inflammation, suggesting its potential as a therapeutic agent for such conditions (Rock et al., 2018).

Inhibition of Cancer Cell Migration: CBDA was found to inhibit migration in highly invasive breast cancer cells, indicating potential as a therapeutic agent in cancer treatment (Takeda et al., 2012)

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What Should I Look For When Buying CBDa Oil?

When buying CBDa oil, consider the concentration of CBDa, source of the hemp, extraction method, and the presence of other cannabinoids. Look for products with lab testing and certification to ensure quality and safety (Formato et al., 2020). Often oils containing CBDa is referred to as Raw CBD-oils.

Is CBDa Safe? What Are The Potential Side Effects?

While CBDa is considered safe and well-tolerated, there's limited research on its long-term effects and potential side effects. It's important to consult healthcare professionals before starting any new supplement regimen, especially for those with pre-existing conditions or taking other medications.

In conclusion

In conclusion, CBDa, the precursor to CBD found in raw cannabis, has shown promising therapeutic potential. Research highlights its effectiveness in reducing anxiety, improving neuromotor tolerability, influencing sleep cycles, and offering antioxidant and anticancer benefits. It also demonstrates potential in treating obesity and inflammatory conditions, and may inhibit the spread of certain cancer cells. When selecting CBDa oil, it's important to consider product quality, concentration, and legality, which varies by region.